A bus crash gives four very different middle schoolers odd super powers, and although they wouldn't normally be caught dead together, they must pool their powers to find out what happened to them.
As their powers evolve in possibly dangerous ways, the Odds learn of a nefarious experiment in which they are unwitting test subjects and, even more incredible, become friends.
While the Odds crew tries to manage their bizarre superpowers, several of their less-than-gifted classmates have become town celebrities thanks to their suspiciously good exam results, prompting Jay and Nick to investigate.